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Title:
Expression of pSTAT3 and TNF-α in Normotensive and Severe Preeclamptic Placentas
Authors:  Cihan Togrul, M.D., Umit Gorkem, M.D., Sevgi Irtegun, Ph.D., Ali Emre Tahaoglu, M.D., Tayfun Gungor, M.D., and Engin Deveci, Ph.D.
  Objective: To examine histopathologic changes and correlation between TNF-α and pSTAT3 expression levels by western blot and immunohistochemical methods in preeclamptic placentas.
Study Design:
Obstetrical properties and biochemical and hematological features of patients with preeclampsia and healthy subjects were compared. Paraffin sections obtained from placenta were stained with hematoxylin-eosin for histopathologic examination.
Results:
In histopathologic examination of preeclamptic placentas, cytotrophoblastic cellular proliferation, fibrinoid necrosis, endothelial proliferation, and calcified and hyalinized villous spots were observed.
Conclusion:
In preeclamptic placentas, we observed that trophoblastic invasion may downregulate STAT3 phosphorylation and can correlate with TNF-α elevation. Even though trophoblast invasion may interfere with both vascular and immune systems, TNF-α is not directly involved in the STAT3 signaling pathway in the preeclamptic placenta.
Keywords:  placenta, preeclampsia, STAT3, TNF-α
   
   
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