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Title:
Expressions of FHIT, BCRP, and Bcl-2 Proteins in Breast Invasive Ductal Carcinoma
Authors:  Wen Yun, M.S., Jinhai Tang, M.D., Jian Li, M.S., and Dawei Sun, M.D.
  Objective: To explore the expressions of FHIT, BCRP, and Bcl-2 proteins in breast invasive ductal carcinoma (IDC) and the relationships with clinical pathological factors.
Study Design:
The expressions of FHIT, BCRP, and Bcl-2 proteins in 84 cases of surgically resected primary breast IDC tissues and another 36 cases of normal breast tissues collected about 3 cm away from the neoplastic foci and pathologically confirmed as normal were detected with the immunohistochemical streptavidin-peroxidase method to analyze the relationships between the 3 proteins and the pathological characteristics of breast IDC.
Results:
The positive expression rates of FHIT, BCRP, and Bcl-2 were 42.86%, 72.62%, and 61.90%, respectively, in the breast IDC group and 72.22%, 36.11%, and 38.89%, respectively, in the normal control group, between which the differences were statistically significant (p<0.05). In the breast IDC group the expressions of the 3 proteins were correlated with lymphatic metastasis and recurrence but were not significantly correlated with the expression of estrogen receptor, progesterone receptor, or proto-oncogene human epidermal growth factor receptor 2. The expression of FHIT was negatively correlated with the expression of Bcl-2 (r=−0.322, −0.389), but BCRP and Bcl-2 expressions were positively correlated (r=0.276).
Conclusion:
Abnormal expressions of FHIT, BCRP, and Bcl-2 proteins may play important roles in the onset and progression of breast IDC.
Keywords:  Bcl-2; bcl-2 Genes; BCRP; breast cancer; breast cancer resistance protein; breast invasive ductal carcinoma; c-bcl-2 proto-oncogenes; FHIT; fragile histidine triad; genes, bcl-2
   
   
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