Sunday, October 22nd, 2017

 

Next
A full text version of this article is available.
To access article obtain online access here or login
 
Title:
Expression of Cyclophilin A in the Placental Tissue of Pregnant Women with Gestational Diabetes Mellitus
Authors:  Akin Usta, M.D., Gulay Turan, M.D., Eren Altun, M.D., Ceyda Sancakli Usta, M.D., and Ertan Adali, M.D.
  Objective: To evaluate placental cyclophilin A (CyPA) expression and assess its association with maternal/fetal health outcomes in pregnant women with gestational diabetes mellitus (GDM).
Study Design:
A total of 43 pregnant women (23 GDM and 20 non-GDM) underwent a 50-g glucose challenge test (GCT) at 24–28 weeks’ gestation. A GCT cutoff of <140 mg/dL was selected. Women with an elevated GCT underwent prompt diagnostic testing via a 3-hour glucose tolerance test. Immunohistochemistry for CyPA was performed on formalin-fixed and paraffin embedded sections. Finally, the relationship between placenta CyPA reactivity and the clinical findings of GDM was evaluated.
Results:
The expression of placental CyPA was significantly different between pregnant women with GDM and non-GDM subjects. There was an increased expression of CyPA in trophoblasts, capillary endothelium, and decidua of GDM pregnancies as compared with those of non-GDM subjects (p=0.0007, 0.0012, and 0.0019, respectively). CyPA expression in the capillary endothelium was correlated with the presence of maternal/fetal complications and placental changes as- sociated with GDM. Additionally, CyPA expression in the trophoblasts was strongly correlated with placental changes.
Conclusion:
The discovered differences indicate a possible relationship between GDM and the immunohistochemical expression of CyPA in placental tissue.
Keywords:  cyclophilin A; cyclophilins; cyclosporins; gestational diabetes mellitus; immunohistochemistry; oxidative stress; peptidyl-prolyl cis-trans isomerase A; peptidylprolyl isomerase; placental histology
   
   
  Acrobat Reader 7.0 is recommended to properly view and print the article.
Reader can be downloaded from